Treatment of Neonatal Enterovirus Infections

Neonatal enterovirus infections reported to the national enterovirus surveillance system in the United States, 1983-2003.

BACKGROUND Neonatal enterovirus (EV) infections lead to a wide range of clinical manifestations, from mild febrile illness to severe, sometimes fatal, sepsislike disease. METHODS To determine the relationship of EV serotypes with the risk of neonatal infection and its fatal outcome, we analyzed data reported to the National Enterovirus Surveillance System (NESS) during 1983-2003. RESULTS Of...

Enterovirus Infections.

During Monday morning clinic in mid-July, you refer 2 cases to the emergency department (ED). The first is a 2-week-old neonate who has had 1 day of decreased oral intake and a temperature of 102°F (38.9°C) at your clinic. The baby appears alert with normal findings on physical examination. Later in themorning you receive an update call from the ED attending physician. Examination of the cerebr...

Enterovirus infections.

Enterovirus infections.

Treatment of potentially life-threatening enterovirus infections with pleconaril.

Enteroviruses usually cause self-limited disease that, although associated with high morbidity, is rarely fatal. In certain patient populations, however, the enteroviruses may cause potentially life-threatening infections. Pleconaril is a novel compound that integrates into the capsid of picornaviruses, including enteroviruses and rhinoviruses, preventing the virus from attaching to cellular re...